Author

Rana Karimpour

University of AlbertaORCID 0000-0002-5503-4836Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:CUT&Tag· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Michael J. HendzeliD· 2 shared Mzwanele NguboiD· 2 shared William L. StanfordiD· 2 shared Amit ShresthaiD· 1 shared Naveen Ahuja· 1 shared Theodore J. PerkinsiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersGenomics

Michael J. HendzelORCID

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2 papers

Recent·Most cited

A multiscale chromatin collapse underlies vascular pathology in Hutchinson -Gilford progeria syndrome

Mzwanele Ngubo, Naveen Ahuja, Rana Karimpour, Amit Shrestha, Michael J. Hendzel, Theodore J. Perkins, William L. Stanford

This study identifies chromatin reorganization and histone mark changes in HGPS VSMCs, linking them to vascular pathology through disrupted enhancer-promoter interactions.

bioRxiv · May 27, 2026 · PreprintGenomics

HDAC2 inhibition restores H4K16ac and delays senescence in HGPS VSMCs

Rana Karimpour, Mzwanele Ngubo, William L. Stanford, Michael J. Hendzel

The paper identifies HDAC2 as the main regulator of H4K16ac in HGPS VSMCs and shows that its inhibition restores acetylation and delays senescence.

bioRxiv · Nov 7, 2025 · PreprintMolecular Biology