Author

Michael J. Hendzel

University of AlbertaORCID 0000-0002-9603-7945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:CUT&Tag· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Mzwanele NguboiD· 2 shared Rana KarimpouriD· 2 shared William L. StanfordiD· 2 shared Amit ShresthaiD· 1 shared Christopher J. NelsoniD· 1 shared Hilmar StrickfadeniD· 1 shared John B. VincentiD· 1 shared Juan AusióiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenomics

Mzwanele NguboORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A multiscale chromatin collapse underlies vascular pathology in Hutchinson -Gilford progeria syndrome

Mzwanele Ngubo, Naveen Ahuja, Rana Karimpour, Amit Shrestha, Michael J. Hendzel, Theodore J. Perkins, William L. Stanford

This study identifies chromatin reorganization and histone mark changes in HGPS VSMCs, linking them to vascular pathology through disrupted enhancer-promoter interactions.

bioRxiv · May 27, 2026 · PreprintGenomics

MeCP2 NID interaction with RNA: Implications for Rett Syndrome-Relevant Protein Regulation

Katrina Good, Hilmar Strickfaden, Tahir Muhammad, John B. Vincent, Michael J. Hendzel, Christopher J. Nelson, Juan Ausió

This study identifies RNA interaction at the NID/RBD of MeCP2 and shows it inhibits MeCP2-NCoR binding, suggesting a role in Rett syndrome pathophysiology.

Human Molecular Genetics · Jan 1, 2026Peer-reviewedMolecular Biology

HDAC2 inhibition restores H4K16ac and delays senescence in HGPS VSMCs

Rana Karimpour, Mzwanele Ngubo, William L. Stanford, Michael J. Hendzel

The paper identifies HDAC2 as the main regulator of H4K16ac in HGPS VSMCs and shows that its inhibition restores acetylation and delays senescence.

bioRxiv · Nov 7, 2025 · PreprintMolecular Biology