William L. Stanford

Differentiating TSC2-null human pluripotent stem cells into neural crest cells models lymphangioleiomyomatosis and reveals TWIST1 and SUN4 as synthetic lethal targets whose antisense knockdown eradicates mouse allograft tumors.

This study identifies chromatin reorganization and histone mark changes in HGPS VSMCs, linking them to vascular pathology through disrupted enhancer-promoter interactions.

The paper identifies HDAC2 as the main regulator of H4K16ac in HGPS VSMCs and shows that its inhibition restores acetylation and delays senescence.

This study identifies pRb as a novel VHL substrate, showing that its hyperstabilization promotes ccRCC tumorigenesis through transcriptional changes.

This study shows that reducing CDK14 genetically or pharmacologically decreases alpha-synuclein pathology and improves symptoms in Parkinson's disease models.