Mechanistic insights and in vivo HIV suppression by the BRD4-targeting small molecule ZL0580
Naveen Sanath Kumar, Zonghui Ma, Fuquan Long, Srinivasa Reddy Bonam, Hsien‐Tsung Lai, Shwu-Yuan Wu, Haiying Chen, Nicholas C. Hazell, Jiani Bei, Xue Liu, Yeqing Chen, Zhi Wei, Cheng‐Ming Chiang, Jia Zhou, Hu Haitao
This study identifies ZL0580 as a BRD4-targeting small molecule that suppresses HIV in vivo through epigenetic mechanisms, showing potent antiviral effects in a humanized mouse model.
PLoS Pathogens · Feb 2, 2026Peer-reviewedMicrobiology