Jiani Bei

Mechanistic insights and in vivo HIV suppression by the BRD4-targeting small molecule ZL0580

This study identifies ZL0580 as a BRD4-targeting small molecule that suppresses HIV in vivo through epigenetic mechanisms, showing potent antiviral effects in a humanized mouse model.

mRNA-delivered neutralizing antibodies confer protection against SARS-CoV-2 variant in the lower and upper respiratory tract

This study develops mRNA-LNPs encoding neutralizing antibodies against SARS-CoV-2, showing protection against the Omicron variant in mouse and hamster models.

Circulating extracellular vesicles from HIV-1 gp120-treated mice act as endogenous algogens, mediating and maintaining HIV-associated chronic pain

Identification of common sequence motifs shared exclusively among selectively packed exosomal pathogenic microRNAs during rickettsial infections

The paper identifies common sequence motifs shared among specific microRNAs in exosomes from rickettsia-infected cells, linking them to microvasculopathy.

Circulating exosomes from Alzheimer's disease suppress VE-cadherin expression and induce barrier dysfunction in recipient brain microvascular endothelial cell

This study shows that Alzheimer's disease circulating exosomes reduce VE-cadherin expression and impair brain endothelial barrier function through RNA cargo-dependent mechanisms.