Author

Nicholas C. Hazell

The University of Texas Medical Branch at Galveston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Organism:Arabidopsis· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Hu HaitaoiD· 2 shared Jessica A. PlanteiD· 2 shared Jiani Bei· 2 shared Kenneth S. PlanteiD· 2 shared Srinivasa Reddy BonamiD· 2 shared Catherine E. Hammond· 1 shared Cheng‐Ming ChiangiD· 1 shared Chenggong JiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

Hu HaitaoORCID

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Author profile →

3 papers

Recent·Most cited

Molecular basis for chikungunya virus recognition of a mosquito-specific receptor

Xiaoyi Fan, Wanyu Li, Jesse S. Plung, Jessica A. Plante, Ellie M. Hajovsky, Nisha Tapryal, Jennifer Diaz, Nicholas C. Hazell, Chenggong Ji, Zhiqi Liu, Catherine E. Hammond, Scott C. Weaver, Kenneth S. Plante, Jonathan Abraham

This study identifies the molecular basis of chikungunya virus recognition of the mosquito-specific receptor Lachesin using cryo-EM structures and shows a Lachesin polymorphism that blocks virus entry.

bioRxiv · Jul 29, 2026 · PreprintMicrobiology

Mechanistic insights and in vivo HIV suppression by the BRD4-targeting small molecule ZL0580

Naveen Sanath Kumar, Zonghui Ma, Fuquan Long, Srinivasa Reddy Bonam, Hsien‐Tsung Lai, Shwu-Yuan Wu, Haiying Chen, Nicholas C. Hazell, Jiani Bei, Xue Liu, Yeqing Chen, Zhi Wei, Cheng‐Ming Chiang, Jia Zhou, Hu Haitao

This study identifies ZL0580 as a BRD4-targeting small molecule that suppresses HIV in vivo through epigenetic mechanisms, showing potent antiviral effects in a humanized mouse model.

PLoS Pathogens · Feb 2, 2026Peer-reviewedMicrobiology

mRNA-delivered neutralizing antibodies confer protection against SARS-CoV-2 variant in the lower and upper respiratory tract

Nicholas C. Hazell, Rachel A. Reyna, Srinivasa Reddy Bonam, Jiani Bei, Naveen Kumar, Tina Nguyen, Jessica A. Plante, David Hughes Walker, Tian Wang, Kenneth S. Plante, Haitao Hu

This study develops mRNA-LNPs encoding neutralizing antibodies against SARS-CoV-2, showing protection against the Omicron variant in mouse and hamster models.

bioRxiv · Apr 28, 2025 · PreprintMicrobiology