B. pertussis, tracheal cytotoxin biases NOD signaling to suppress IL-1 mediated inflammation and evade adaptive immunity
David M. Rickert, Elizabeth Hill, Riley Himmelberger, Neeta Rajbanshi, Sasha Cardozo, Tialfi Bergamin de Castro, Ravi Bharadwaj, Alison J. Scott, Neal S. Silverman, William E. Goldman, Nicholas H. Carbonetti, Karen M. Scanlon, Ciaran M. Skerry
This study shows that B. pertussis releases tracheal cytotoxin (TCT), which biases NOD1 over NOD2 signaling, suppresses IL-1β inflammation, and evades adaptive immunity.
bioRxiv · Aug 8, 2025 · PreprintMicrobiology