Author

Karen M. Scanlon

University of Maryland, BaltimoreORCID 0000-0002-5300-8749Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:experimental assay· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ciaran M. SkerryiD· 2 shared David M. RickertiD· 2 shared Nicholas H. CarbonettiiD· 2 shared Sasha CardozoiD· 2 shared William E. GoldmaniD· 2 shared Alison J. ScottiD· 1 shared Elizabeth Hill· 1 shared Neal S. SilvermaniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Ciaran M. SkerryORCID

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2 papers

Recent·Most cited

A dual role for PGLYRP1 in host defense and immune regulation during B. pertussis infection

David M. Rickert, Sasha Cardozo, Nicholas H. Carbonetti, William E. Goldman, Karen M. Scanlon, Ciaran M. Skerry

This study identifies a dual role for PGLYRP1 in modulating immune responses to B. pertussis, both enhancing antibacterial defenses and dampening inflammation.

bioRxiv · Sep 26, 2025Microbiology

B. pertussis, tracheal cytotoxin biases NOD signaling to suppress IL-1 mediated inflammation and evade adaptive immunity

David M. Rickert, Elizabeth Hill, Riley Himmelberger, Neeta Rajbanshi, Sasha Cardozo, Tialfi Bergamin de Castro, Ravi Bharadwaj, Alison J. Scott, Neal S. Silverman, William E. Goldman, Nicholas H. Carbonetti, Karen M. Scanlon, Ciaran M. Skerry

This study shows that B. pertussis releases tracheal cytotoxin (TCT), which biases NOD1 over NOD2 signaling, suppresses IL-1β inflammation, and evades adaptive immunity.

bioRxiv · Aug 8, 2025 · PreprintMicrobiology