Nicholas H. Carbonetti

Interferon lambda drives immunological maturation in the infant lung and protects against lethal Bordetella pertussis infection

This study shows that interferon lambda is crucial for immune maturation in infant lungs and protects against lethal pertussis infection by enhancing immune responses and limiting bacterial spread.

A dual role for PGLYRP1 in host defense and immune regulation during B. pertussis infection

This study identifies a dual role for PGLYRP1 in modulating immune responses to B. pertussis, both enhancing antibacterial defenses and dampening inflammation.

B. pertussis, tracheal cytotoxin biases NOD signaling to suppress IL-1 mediated inflammation and evade adaptive immunity

This study shows that B. pertussis releases tracheal cytotoxin (TCT), which biases NOD1 over NOD2 signaling, suppresses IL-1β inflammation, and evades adaptive immunity.