Pathogenicity of autoreactive TH17 cells is modulated by the TRPM7 kinase
Katharina Jacob, Anna S. Thomann, Anna Madlmayr, Katharina Hörner, Neysa Rodriguez Murillo, Dorothea Lewitz, Franz Bauerschmitt, Lisa Ann Gerdes, C Weber, Hendrick Schulze-Koops, Masayuki Matsushita, Thomas W. Gudermann, Birgit Karner-Hoeger, Anneli Peters, Susanna Zierler
This study shows TRPM7 kinase activity modulates pathogenic TH17 cell differentiation and function, with reduced TRPM7 activity leading to milder EAE and increased Tregs in mice.
bioRxiv · Nov 1, 2026 · PreprintImmunology