Author

Dorothea Lewitz

Walther-Straub-Institut für Pharmakologie und Toxikologie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Anna MadlmayriD· 2 shared Katharina Hörner· 2 shared Susanna ZierleriD· 2 shared Thomas W. GudermanniD· 2 shared Alexander DietrichiD· 1 shared Anna S. ThomanniD· 1 shared Anneli PetersiD· 1 shared Birgit HoegeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Anna MadlmayrORCID

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2 papers

Recent·Most cited

Pathogenicity of autoreactive TH17 cells is modulated by the TRPM7 kinase

Katharina Jacob, Anna S. Thomann, Anna Madlmayr, Katharina Hörner, Neysa Rodriguez Murillo, Dorothea Lewitz, Franz Bauerschmitt, Lisa Ann Gerdes, C Weber, Hendrick Schulze-Koops, Masayuki Matsushita, Thomas W. Gudermann, Birgit Karner-Hoeger, Anneli Peters, Susanna Zierler

This study shows TRPM7 kinase activity modulates pathogenic TH17 cell differentiation and function, with reduced TRPM7 activity leading to milder EAE and increased Tregs in mice.

bioRxiv · Nov 1, 2026 · PreprintImmunology

TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner

Anna Madlmayr, Kilian Hoelting, Birgit Hoeger, Dorothea Lewitz, Marius Weng, Severin Hacker, Julia Eder, Katharina Hörner, Christine Schedlberger, Tanja Haider, Max Lechner, Michelle Duggan, Rylee Ross, F. David Horgen, Markus Sperandio, , Susanna Zierler

This study shows TRPM7 is essential for human CD4 T-cell activation and differentiation through Mg2+ dependent Ca2+ signaling and NFAT translocation.

Life Science Alliance · Nov 17, 2025Peer-reviewedImmunology