Thomas W. Gudermann

Pathogenicity of autoreactive TH17 cells is modulated by the TRPM7 kinase

This study shows TRPM7 kinase activity modulates pathogenic TH17 cell differentiation and function, with reduced TRPM7 activity leading to milder EAE and increased Tregs in mice.

Tracheal tuft cell-released leukotrienes promote antibacterial immune responses

This study identifies tracheal tuft cells as sources of leukotrienes that promote antibacterial immune responses by detecting bacterial ATP via Trpm5.

Cigarette Smoke Extract (CSE) reduces expression of functional TRPV4 channels in primary human bronchial epithelial cells differentiated at an Air Liquid Interface (ALI) in vitro

This study shows that cigarette smoke extract reduces TRPV4 protein expression and function in human bronchial epithelial cells, potentially contributing to COPD.

TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner

This study shows TRPM7 is essential for human CD4 T-cell activation and differentiation through Mg2+ dependent Ca2+ signaling and NFAT translocation.

TRPV2 and TRPM2 channels facilitate pulmonary endothelial barrier recovery after ROS-induced permeability