Dengue Virus NS1 Binds Ephrin B1 to Trigger Endothelial Dysfunction
Felix Pahmeier, Sabrina Hammond, Charlotte Flory, Xinyi Feng, S. Lee, Erika Vanessa Jiménez-Posada, Elias Michael Duarte, Jaime Andrés Cardona-Ospina, Aquena H. Ball, Nharae E. Lee, Kayla Leung, Laurentia V. Tjang, P. Robert Beatty, Scott B. Biering, Pietro Scaturro, Eva Harris
This study identifies ephrin B1 as a host factor mediating dengue virus NS1-induced endothelial barrier dysfunction and shows EFNB1-Fc fusion proteins can block this effect.
bioRxiv · Nov 19, 2025 · PreprintMicrobiology