Eva Harris

Dengue virus-specific memory B cell subsets differ as a function of infection history

This study compares DENV-specific memory B cell subsets in primary and secondary dengue infections, finding qualitative differences in subset frequencies and timing of peak responses.

Flavivirus NS1-triggered endothelial dysfunction promotes virus dissemination

This study shows that flavivirus NS1 promotes virus dissemination by causing endothelial dysfunction, both in vitro and in vivo, and suggests NS1 as a therapeutic target.

Dengue Virus NS1 Binds Ephrin B1 to Trigger Endothelial Dysfunction

This study identifies ephrin B1 as a host factor mediating dengue virus NS1-induced endothelial barrier dysfunction and shows EFNB1-Fc fusion proteins can block this effect.

A novel method for characterizing cell-cell interactions at single-cell resolution reveals unique signatures in blood T cell-monocyte complexes during infection

The paper introduces a method to study cell-cell interactions at single-cell resolution, revealing unique transcriptomic signatures in T cell-monocyte complexes during TB and dengue infection.

Therapeutic Potential of Cyclodextrins Targeting Dengue Virus and SARS-CoV-2 Infection and Pathogenesis

This study evaluates cyclodextrins' ability to reduce endothelial dysfunction and antiviral activity against DENV and SARS-CoV-2 in vitro and in vivo.

Cytoplasmic mRNA decay by the anti-viral nuclease RNase L promotes transcriptional repression

This study shows that RNase L, an antiviral nuclease, represses transcription by reducing RNA polymerase II elongation, particularly affecting immune-related genes.

Identification of immunogenic and cross-reactive chikungunya virus-specific CD4+ T cell epitopes in chronic chikungunya viral arthritic disease in humans

This study identifies CD4+ T cell epitopes in chronic chikungunya virus disease, revealing conserved epitopes across alphaviruses and providing tools for T cell response analysis.

Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread

This study identifies GP38 as a viral toxin causing vascular leak and shows that specific GP38-targeting antibodies block this effect in vitro and in vivo.

Tracking the genetic diversity of SARS-CoV-2 variants in Nicaragua throughout the COVID-19 Pandemic

This study tracks SARS-CoV-2 genetic diversity in Nicaragua from 2020 to 2022, showing lineage shifts and linking mutations to hospitalization rates.

A numbers game: Mosquito-based arbovirus surveillance in two distinct geographic regions of Latin America

This study conducts mosquito-based arbovirus surveillance in Nicaragua and Ecuador, detecting DENV in mosquito pools during the rainy season with varying infection rates between regions.

Perturbed pediatric serum metabolome in mild and severe dengue disease

The paper identifies a metabolic biomarker panel that distinguishes dengue fever from severe dengue forms and provides insights into disease pathology.

The Immune Signatures Data Resource: A compendium of systems vaccinology datasets

The paper introduces the Immune Signatures Data Resource, a compendium of standardized systems vaccinology datasets for comparative vaccine response analysis.

Genome-wide, bidirectional CRISPR screens identify mucins as critical host factors modulating SARS-CoV-2 infection

The paper uses CRISPR screens to identify mucins as key host factors that restrict SARS-CoV-2 infection in human lung cells.

Capturing diverse microbial sequence with comprehensive and scalable probe design

The paper introduces CATCH, a method for designing compact and scalable probe sets to enhance metagenomic sequencing sensitivity, demonstrating improved viral genome recovery and diversity preservation.

Immuno-proteomic interrogation of dengue infection reveals novel HLA haplotype-specific MHC-I antigens

This study identifies novel MHC-I antigens specific to dengue virus infection using an immuno-proteomics approach, revealing ligands associated with distinct HLA haplotypes and T-cell recognition.