Laurentia V. Tjang

This study determines cryo-EM structures of orthoflaviviruses bound to LDLR family receptors, revealing distinct binding modes and receptor engagement mechanisms.

This study identifies ephrin B1 as a host factor mediating dengue virus NS1-induced endothelial barrier dysfunction and shows EFNB1-Fc fusion proteins can block this effect.

The paper identifies receptor-binding polymorphisms in WEEV that explain shifts in receptor dependencies and enable nonpathogenic strains to infect neurons.

This paper introduces a method to rewrite large genomic regions using CRISPR/Cas9, enabling simultaneous editing of 7kb+ DNA sections without selection.