Author

Nic Buchholz

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Assay:structural biology· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Andrew P. HinckiD· 1 shared Brian CoventryiD· 1 shared Buwei HuangiD· 1 shared Christopher J. KimiD· 1 shared Clara McCurdyiD· 1 shared Cynthia S. HinckiD· 1 shared David A. BakeriD· 1 shared David S. LeeiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Andrew P. HinckORCID

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1 paper

Recent·Most cited

Improved protein binder design using -pairing targeted RFdiffusion

Isaac Sappington, Martin Toul, David S. Lee, Stephanie A. Robinson, Inna Goreshnik, Clara McCurdy, Tung Ching Chan, Nic Buchholz, Buwei Huang, Dionne K. Vafeados, Mariana Garcia-Sanchez, Nicole Roullier, Matthias Glögl, Christopher J. Kim, Joseph L. Watson, , David A. Baker

Conditioning RFdiffusion on edge beta-strand pairing yields specific binders to polar targets, with in silico success above 9.2% versus 0.98% for hotspot-only conditioning.

Nature Communications · Jan 10, 2026Peer-reviewedBiochemistry✦ In-depth digest