Author

Tung Ching Chan

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Andrew P. HinckiD· 1 shared Arvind Rasi SubramaniamiD· 1 shared Brian CoventryiD· 1 shared Buwei HuangiD· 1 shared Christopher J. KimiD· 1 shared Christopher P. LapointeiD· 1 shared Clara McCurdyiD· 1 shared Cynthia S. HinckiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

Andrew P. HinckORCID

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2 papers

Recent·Most cited

A codon-sensitive conformational switch gates commitment to translation start sites

Sydney F. McGuire, Matthew C. Chan, Tung Ching Chan, Niseema D. Pachikara, Eva M. Alleman, Veronica Sikora, Arvind Rasi Subramaniam, Melody G. Campbell, Christopher P. Lapointe

The paper identifies a conformational switch in eIF5 that regulates translation initiation at AUG and non-AUG codons by stabilizing or destabilizing the initiation complex.

bioRxiv · Mar 27, 2026 · PreprintBiophysics

Improved protein binder design using -pairing targeted RFdiffusion

Isaac Sappington, Martin Toul, David S. Lee, Stephanie A. Robinson, Inna Goreshnik, Clara McCurdy, Tung Ching Chan, Nic Buchholz, Buwei Huang, Dionne K. Vafeados, Mariana Garcia-Sanchez, Nicole Roullier, Matthias Glögl, Christopher J. Kim, Joseph L. Watson, , David A. Baker

Conditioning RFdiffusion on edge beta-strand pairing yields specific binders to polar targets, with in silico success above 9.2% versus 0.98% for hotspot-only conditioning.

Nature Communications · Jan 10, 2026Peer-reviewedBiochemistry✦ In-depth digest