Author

Nicholas C Forsyth

The Ohio State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

Benjamin PastoreiD· 1 shared Durga AttiliiD· 1 shared Julia E. Warrick· 1 shared Michael G. KearseiD· 1 shared Sami J. BarmadaiD· 1 shared Sarah E. Hoffmann-Weitsman· 1 shared Trevor van EeuweniD· 1 shared Wen TangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperBiochemistry

Benjamin PastoreORCID

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1 paper

Recent·Most cited

An autism spectrum disorder mutation in Topoisomerase 3B causes accumulation of covalent mRNA intermediates by disrupting metal binding within the zinc finger domain

Julia E. Warrick, Durga Attili, Trevor van Eeuwen, Benjamin Pastore, Sarah E. Hoffmann-Weitsman, Nicholas C Forsyth, Wen Tang, Sami J. Barmada, Michael G. Kearse

This study shows that an autism-linked TOP3B mutation causes mRNA covalent intermediates by disrupting metal binding in the zinc finger domain, leading to neuronal toxicity.

Nucleic Acids Research · Oct 15, 2025Peer-reviewedBiochemistry