Wen Tang

The paper shows RNA polymerase II and III form distinct foci at a gene cluster in C. elegans, with different behaviors and regulation across the cell cycle.

This study identifies LOTUS-domain proteins as catalysts for Vasa activity in germ granule assembly across species, showing their role in recruiting Vasa and enhancing RNA binding.

The paper shows HCP-1, a kinetochore component, forms perinuclear condensates in C. elegans germline and associates with nuclear pore proteins, affecting germ cell proliferation and spindle assembly.

This study shows that an autism-linked TOP3B mutation causes mRNA covalent intermediates by disrupting metal binding in the zinc finger domain, leading to neuronal toxicity.

The paper identifies Sm-site containing mRNAs that can accept Sm-rings and shows their downregulation in Spinal Muscular Atrophy.

This study shows FMRP stalls ribosomes and promotes no-go mRNA decay of specific transcripts, revealing a new role in FXS pathogenesis.

The paper shows that PARN-1 3' trimming prevents erroneous piRNA targeting by RDE-3 and EGO-1 in C. elegans, leading to anti-piRNA accumulation.

This study compares piRNA sequences, targets, and functions in C. briggsae and C. elegans, revealing conserved genomic organization and divergent small RNA amplification patterns.

The paper identifies piRNA binding sites in C. elegans germline mRNAs and shows piRNA targeting follows microRNA-like rules, with binding energy more important than piRNA abundance.