Benjamin Pastore

This study shows that an autism-linked TOP3B mutation causes mRNA covalent intermediates by disrupting metal binding in the zinc finger domain, leading to neuronal toxicity.

The paper identifies Sm-site containing mRNAs that can accept Sm-rings and shows their downregulation in Spinal Muscular Atrophy.

This study shows FMRP stalls ribosomes and promotes no-go mRNA decay of specific transcripts, revealing a new role in FXS pathogenesis.

The paper shows that PARN-1 3' trimming prevents erroneous piRNA targeting by RDE-3 and EGO-1 in C. elegans, leading to anti-piRNA accumulation.

This study compares piRNA sequences, targets, and functions in C. briggsae and C. elegans, revealing conserved genomic organization and divergent small RNA amplification patterns.