Julia E. Warrick

An autism spectrum disorder mutation in Topoisomerase 3B causes accumulation of covalent mRNA intermediates by disrupting metal binding within the zinc finger domain

This study shows that an autism-linked TOP3B mutation causes mRNA covalent intermediates by disrupting metal binding in the zinc finger domain, leading to neuronal toxicity.

Single-base m6A epitranscriptomics reveals novel HIV-1 host interaction targets in primary CD4+ T cells

This study identifies m6A RNA modifications and their role in HIV-1 infection of primary CD4+ T cells, showing cell-type specific effects on PLIN3 expression and HIV-1 production.

A non-canonical RNA-binding domain of the Fragile X protein, FMRP, elicits translational repression independent of mRNA G-quadruplexes

This study identifies a non-canonical RNA-binding domain in FMRP that mediates translational repression without requiring mRNA G-quadruplexes.