Intestinal catabolism of dietary fructose promotes obesity and insulin resistance via ileal lacteal remodeling
Miranda L. Lopez, Taekyung Kang, Ana M. Espeleta, Varvara I. Rubtsova, Jongwon Baek, Jakob Songcuan, Elena M. Moyer, Joo‐Hwan Kim, Won-Suk Song, Sunhee Jung, Nicholas D’Sa, Alexis L. Anica, Elise Tran, Yujin Chun, Wonsuk Choi, , Cholsoon Jang
This study shows that blocking intestinal fructose catabolism reduces obesity and insulin resistance by decreasing fat absorption and altering gut microbiome and immune interactions.
bioRxiv · Aug 18, 2025 · PreprintPhysiology