Nikolas Nikolaidis

Lipid-Gated Vesicular Trafficking Directs HSPA1A to the Plasma Membrane Through the Endo-Lysosomal Network

This study identifies a lipid-gated vesicular trafficking pathway for HSPA1A to the plasma membrane via the endo-lysosomal network, highlighting lysosomal BMP and endosomal PI(4)P as regulatory factors.

Population-associated molecular variation in histologically normal breast tissue is context-dependent and associated with distinct transcriptional states

The paper identifies context-dependent transcriptional states in normal breast tissue that show population-associated differences, with distinct biological programs in specific tissue contexts.

Heat Shock-Induced PI(4)P Increase Drives HSPA1A Translocation to the Plasma Membrane in Cancer and Stressed Cells through PI4KIII Alpha Activation

Dynamic Lipidome Reorganization in Response to Heat Shock Stress

This study investigates lipidomic and transcriptomic changes in HeLa cells under heat shock and recovery, revealing extensive lipid remodeling and transcriptional regulation.

Transcriptomics Unveil Canonical and Non-Canonical Heat Shock-Induced Pathways in Human Cell Lines

The paper compares transcriptomic responses to heat shock in three human cell lines, identifying conserved and cell-specific pathways.

PRRGO: A Tool for Visualizing and Mapping Globally Expressed Genes in Public Gene Expression Omnibus RNA-Sequencing Studies to PageRank-scored Gene Ontology Terms

PRRGO integrates differentially expressed genes from GEO with gene ontology data to generate PageRank-scored GO terms for hypothesis generation.