Luis E. Solano

FORGE is a configurable Nextflow pipeline for snMultiome analysis that integrates snRNA-seq and snATAC-seq data through latent-variable models and enables regulatory network inference and differential testing.

This study investigates lipidomic and transcriptomic changes in HeLa cells under heat shock and recovery, revealing extensive lipid remodeling and transcriptional regulation.

The paper compares transcriptomic responses to heat shock in three human cell lines, identifying conserved and cell-specific pathways.

PRRGO integrates differentially expressed genes from GEO with gene ontology data to generate PageRank-scored GO terms for hypothesis generation.