Soluble pathogenic tau transmission to astrocytes drives acute oxidative damage, cellular senescence, and neurovascular uncoupling in a model of Alzheimers tauopathy
Haneen Makhlouf, Angela O. Dorigatti, Stephen F. Hernandez, Nicholas de Rosa, Lauren R. Miller, Stacy A. Hussong, Deborah M. Holstein, James Donald Lechleiter, Sreemathi Logan, Rakez Kayed, Verónica Galván
This study shows that soluble pathogenic tau aggregates are transmitted to astrocytes, causing mitochondrial dysfunction, senescence, and neurovascular uncoupling in a tauopathy model.
bioRxiv · Sep 14, 2026 · PreprintNeuroscience