Matrix stiffness induces heritable changes in chromosome numbers, consistent with solid tumor heterogeneity
Alişya A. Anlaş, Markus T. Sprenger, Mai Wang, Nick Ontko, Steven Phan, Dennis E. Discher
The paper shows matrix stiffness induces heritable chromosome changes in cells, linking mechanical stress to genetic instability in solid tumors.
bioRxiv · Jan 28, 2025 · PreprintBiophysics