Dennis E. Discher

The paper shows that cell confinement causes delayed, heritable chromosome loss, which is linked to mitotic memory and has implications for cancer evolution.

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

This study shows that macrophage clusters enhance tumor phagocytosis through coordinated intrudopodia extending between cancer cells.

The paper shows matrix stiffness induces heritable chromosome changes in cells, linking mechanical stress to genetic instability in solid tumors.

The paper examines how tissue stiffness scales with collagen levels across different tissues and finds sub-linear scaling that aligns with cellularized gels, suggesting contractility-driven strain inhibition of collagen degradation.

This paper investigates how mechanical strain affects collagen degradation in tendon and heart tissues, finding that moderate strains suppress degradation while higher strains do not.

The paper monitors live cell fluorescence to quantify aneuploidy-inducing perturbations in lung cancer and iPS cells, revealing increased chromosome mis-segregation and rare fluorescent-null cells.

The paper shows that constricted migration causes nuclear rupture and DNA damage, which are linked to cell cycle repression and DNA repair defects in cancer cells.

The paper shows that constricted cell migration in stiff tissues causes nuclear lamina damage, DNA breaks, and loss of repair factors, leading to genomic instability.