Gut bacterial Infection drives Parkinsonian pathology in LRRK2 G2019S Knock-in Mice
Yuhang Wang, Matthew A. Weber, Nick Stodden, Lily Ziebarth, Sivakumar Lingappa, Monserrath Borjabustamante, Tharoon Balakrishnan, Manab Jaily, Taylor Sakaguchi, Ramasamy Thangavel, Wen Wen, Jia Luo, Nandakumar S. Narayanan, Zizhen Kang
This study shows that LRRK2 G2019S mutation in mice, when combined with recurrent bacterial infection, leads to Parkinson's-like pathology.
bioRxiv · Aug 11, 2026 · PreprintImmunology