Matthew A. Weber

This study shows that LRRK2 G2019S mutation in mice, when combined with recurrent bacterial infection, leads to Parkinson's-like pathology.

The paper investigates dopamine dynamics in the mouse dorsomedial striatum during interval timing and finds that dopamine ramps down before reward delivery, predicts timing behavior, and varies between sexes and with amphetamine.

This study shows that prefrontal neuronal ramping and theta activity occur during both freely-moving and head-fixed interval timing tasks in mice, suggesting they are features of temporal behavior rather than specific motor programs.

This study investigates how time estimation, movement, and reward anticipation contribute to prefrontal and striatal ramping activity in mice during interval timing tasks.

This study shows that VTA dopamine neurons control timing variability in Parkinson's disease by modulating neural activity during interval timing tasks.

The paper investigates prefrontal projections during interval timing, finding distinct temporal coding and transcriptomic profiles in PFC-MD and PFC-DMS circuits.

This study shows that the alpha 1-adrenergic antagonist terazosin enhances glycolysis and is neuroprotective in Alzheimer's disease by reducing amyloid pathology and slowing cognitive decline.

This study shows D2-MSNs and D1-MSNs have opposing dynamics but complementary roles in interval timing, revealing how striatal pathways contribute to cognitive timing.

This study examines how prenatal stress affects dorsal striatum cell types and behaviors in mice, identifying gene expression changes linked to neurodevelopmental disorders.

This study shows amphetamine increases timing variability by reducing prefrontal cortex ramping activity and neural interactions in mice.

The paper investigates sex differences in interval timing across humans and rodents, finding no sex differences in timing accuracy or precision but distinct dopaminergic effects in males.

This study shows that RGS6 in VTA dopamine neurons promotes EtOH seeking, reward, and relapse by enhancing DA transmission through GPCR-Gi/o-DAT signaling.

This study performs a meta-analysis of prefrontal dopamine and D1-receptor manipulations on working memory, finding a negative quadratic relationship explaining 10% of variance.

This study examines interval timing deficits in P301S tau transgenic mice, finding they consistently underestimate temporal intervals compared to wild-type controls.

The paper shows that with experience, striatal neurons improve temporal decoding and exhibit experience-related changes in activity patterns during interval timing tasks in mice.

The paper examines how neuronal ensembles in the medial frontal cortex and dorsomedial striatum change during temporal learning in rodents.