Wen Wen

This study shows that LRRK2 G2019S mutation in mice, when combined with recurrent bacterial infection, leads to Parkinson's-like pathology.

This study shows that deficiency of MANF worsens acute pancreatitis in mice, with sex-specific effects on inflammation and oxidative stress.

This study shows alcohol disrupts neural differentiation by inducing ER stress and PERK pathway activation in both in vitro and in vivo models of prenatal alcohol exposure.

This study shows that MANF levels decline with age in mice and that MANF deficiency affects neurobehavioral functions differently in males and females.

This study uses spatial transcriptomics to show that MANF deficiency in Purkinje cells increases ER stress and vulnerability to alcohol-induced neurodegeneration in a sex-dependent manner in mice.