Nandakumar S. Narayanan

This study shows that LRRK2 G2019S mutation in mice, when combined with recurrent bacterial infection, leads to Parkinson's-like pathology.

The paper investigates dopamine dynamics in the mouse dorsomedial striatum during interval timing and finds that dopamine ramps down before reward delivery, predicts timing behavior, and varies between sexes and with amphetamine.

This study shows that prefrontal neuronal ramping and theta activity occur during both freely-moving and head-fixed interval timing tasks in mice, suggesting they are features of temporal behavior rather than specific motor programs.

This study shows that loss of ASIC1A in the basolateral amygdala increases CO2-evoked jumping and reduces freezing in mice.

This study investigates how time estimation, movement, and reward anticipation contribute to prefrontal and striatal ramping activity in mice during interval timing tasks.

This study shows that VTA dopamine neurons control timing variability in Parkinson's disease by modulating neural activity during interval timing tasks.

The paper investigates prefrontal projections during interval timing, finding distinct temporal coding and transcriptomic profiles in PFC-MD and PFC-DMS circuits.

This study shows that the alpha 1-adrenergic antagonist terazosin enhances glycolysis and is neuroprotective in Alzheimer's disease by reducing amyloid pathology and slowing cognitive decline.

This study shows D2-MSNs and D1-MSNs have opposing dynamics but complementary roles in interval timing, revealing how striatal pathways contribute to cognitive timing.

This study examines how prenatal stress affects dorsal striatum cell types and behaviors in mice, identifying gene expression changes linked to neurodevelopmental disorders.

The paper generates and validates a Drd1-Flpo knock-in mouse line that expresses Flp recombinase specifically in D1DR+ neurons, enabling intersectional genetic studies of these neurons.

This study shows amphetamine increases timing variability by reducing prefrontal cortex ramping activity and neural interactions in mice.

The paper investigates sex differences in interval timing across humans and rodents, finding no sex differences in timing accuracy or precision but distinct dopaminergic effects in males.

This study shows that RGS6 in VTA dopamine neurons promotes EtOH seeking, reward, and relapse by enhancing DA transmission through GPCR-Gi/o-DAT signaling.

This study investigates how dopamine modulates hippocampal-prefrontal network synchrony in rats, finding that dopamine dose-dependently increases theta synchrony without requiring specific receptor subtype activation.

This study performs a meta-analysis of prefrontal dopamine and D1-receptor manipulations on working memory, finding a negative quadratic relationship explaining 10% of variance.

This study examines interval timing deficits in P301S tau transgenic mice, finding they consistently underestimate temporal intervals compared to wild-type controls.

This study investigates the role of the 2{delta}-4 subunit of Cav Ca2+ channels in mice, finding behavioral impairments in motor function and sensorimotor gating.

This study investigates whether cortical injection of alpha-synuclein preformed fibrils (PFF) affects interval timing in mice, finding no consistent deficits despite synucleinopathy.

The paper shows that with experience, striatal neurons improve temporal decoding and exhibit experience-related changes in activity patterns during interval timing tasks in mice.

This study links cognitive dysfunction in Parkinson's disease to increased timing variability and reduced midfrontal ~4 Hz EEG activity during interval timing tasks.

The paper examines frontal theta and beta oscillations in Parkinson’s disease patients during lower-limb movement, finding correlations between these oscillations and motor symptoms.

The paper examines how neuronal ensembles in the medial frontal cortex and dorsomedial striatum change during temporal learning in rodents.

This study shows that stimulating corticostriatal pathways compensates for medial frontal cortex inactivation, improving interval timing behavior in mice.

This study investigates how scopolamine affects interval timing in mice by examining changes in medial frontal cortex activity, finding that it impairs timing but does not alter time-related ramping.

The paper investigates the role of prefrontal D1 dopamine-receptor neurons in interval timing using optogenetics and finds that delta-frequency coherence and early stimulation improve timing performance in dopamine-depleted animals.