GAT1508, a selective neuronal GIRK1/2 activator, exhibits superior antiepileptic efficacy and synergizes with cannabidiol
Jahnavi Simhadri, Andrew Zorn, Liang Wang, Takeharu Kawano, Natalia Cordero Ruiz, Lida Evmorfia Vagiaki, Nousheen Parvaiz, Mehreen Parvaiz, Lucas Cantwell, Kim Chan, Ana Santa‐Cruz, Evangelos Dadiotis, Nicole Rivera, Wilder Felix, Ganesh A. Thakur, , Stelios M. Smirnakis
This study characterizes GAT1508, a selective neuronal GIRK1/2 activator, showing superior antiepileptic efficacy and synergy with CBD.
bioRxiv · Oct 16, 2026 · PreprintPharmacology & Toxicology