Single cell derived organoids capture the self-renewing subpopulations of metastatic ovarian cancer
Tania Velletri, Emanuele Carlo Villa, Michela Lupia, Pietro Lo Riso, Raffaele Luongo, Alejandro Lopez Tobon, Marco De Simone, Raoul J.P. Bonnal, Saverio Minucci, Stefano Piccolo, Nicoletta Colombo, Massimiliano Pagani, Ugo Cavallaro, Giuseppe Testa
This study develops a method to grow single-cell derived ovarian cancer organoids from patient ascites, which retain key subpopulations and features of the original metastasis not seen in 2D cultures.
bioRxiv · Nov 30, 2018 · PreprintCancer Biology