Pietro Lo Riso

This paper develops a novel integration method for highly heterogeneous single-cell transcriptomic data and applies it to high-grade serous ovarian cancer to generate a reference atlas, revealing disease progression and treatment-related cell states.

This study uses human cortical organoids to show that GSK3 inhibition affects progenitor proliferation and tissue architecture, with specific impacts on outer radial glia and astrogenic lineage.

This study develops a method to grow single-cell derived ovarian cancer organoids from patient ascites, which retain key subpopulations and features of the original metastasis not seen in 2D cultures.