Massimiliano Pagani

Acquisition of an immunosuppressive microenvironment after CAR-T therapy drives T-cell dysfunction and resistance

This study shows that CAR-T therapy induces an immunosuppressive microenvironment, leading to T-cell dysfunction and resistance in B-ALL patients.

Open-ST: High-resolution spatial transcriptomics in 3D

Open-ST provides a high-resolution, 3D spatial transcriptomics method to study tissue molecular organization, revealing spatially contiguous structures and biomarkers in tumors and lymph nodes.

The enhancement of activity rescues the establishment of Mecp2 null neuronal phenotypes

This study shows that enhancing neuronal activity rescues developmental defects in Mecp2 null neurons, improving their maturation and extending lifespan in a mouse model of Rett syndrome.

Human cortical organoids expose a differential function of GSK3 on direct and indirect neurogenesis

This study uses human cortical organoids to show that GSK3 inhibition affects progenitor proliferation and tissue architecture, with specific impacts on outer radial glia and astrogenic lineage.

Single cell derived organoids capture the self-renewing subpopulations of metastatic ovarian cancer

This study develops a method to grow single-cell derived ovarian cancer organoids from patient ascites, which retain key subpopulations and features of the original metastasis not seen in 2D cultures.