Synthetic regulatory genomics uncovers enhancer context dependence at the Sox2 locus
Ran Brosh, Camila Coelho, André Mauricio Ribeiro-dos-Santos, Gwen Ellis, Megan S. Hogan, Hannah J. Ashe, Nicolette Somogyi, Raquel Ordóñez, Raven D. Luther, Emily Huang, Jef D. Boeke, Matthew T. Maurano
The paper uses synthetic regulatory genomics to study Sox2 expression in mESCs, finding that some enhancer regions are context-dependent and can enhance core regulatory elements.
Molecular Cell · Mar 16, 2023Peer-reviewedGenomics