Colitis-primed circulating T cells drive small intestinal barrier function through Nod2, microbiota and myosin light chain kinase-dependent mechanisms
Arthur Mauduit, Talal Nabhani, Luisa Morelli, Floriane Cherrier, Rosemary Abdoul Ahad, Nidal Nabhani, Gurminder Singh, Maryline Roy, Gilles Dietrich, Jerrold R. Turner, Jean‐Pierre Hugot, Andrew James Macpherson, Emmanuel Mas, Frédérick Barreau, Ziad Al Nabhani
This study shows that colitis-primed T cells affect small intestinal barrier function via Nod2, microbiota, and MLCK mechanisms, with distinct roles for hematopoietic and non-hematopoietic Nod2.
bioRxiv · Jul 10, 2025 · PreprintImmunology