Author

Jean‐Pierre Hugot

Assistance Publique – Hôpitaux de ParisORCID 0000-0002-8446-6056Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Alexandre FabreiD· 1 shared Andrew James MacphersoniD· 1 shared Ange‐Line BrueliD· 1 shared Arnaud Blanchard· 1 shared Arnauld Delarue· 1 shared Arthur Mauduit· 1 shared Aurélie Bourchany· 1 shared Bertrand RoquelaureiD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

Alexandre FabreORCID

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2 papers

Recent·Most cited

Colitis-primed circulating T cells drive small intestinal barrier function through Nod2, microbiota and myosin light chain kinase-dependent mechanisms

Arthur Mauduit, Talal Nabhani, Luisa Morelli, Floriane Cherrier, Rosemary Abdoul Ahad, Nidal Nabhani, Gurminder Singh, Maryline Roy, Gilles Dietrich, Jerrold R. Turner, Jean‐Pierre Hugot, Andrew James Macpherson, Emmanuel Mas, Frédérick Barreau, Ziad Al Nabhani

This study shows that colitis-primed T cells affect small intestinal barrier function via Nod2, microbiota, and MLCK mechanisms, with distinct roles for hematopoietic and non-hematopoietic Nod2.

bioRxiv · Jul 10, 2025 · PreprintImmunology

Osteo-Oto-Hepato-Enteric Syndrome (O2HE) is caused by loss of function mutations in UNC45A

Clothilde Estève, Ludmila Francescatto, Perciliz L. Tan, Aurélie Bourchany, Cécile de Leusse, Evelyne Marinier, Arnaud Blanchard, Patrice Bourgeois, Céline Brochier‐Armanet, Ange‐Line Bruel, Arnauld Delarue, Yannis Duffourd, Emmanuelle Ecochard‐Dugelay, Geraldine Hery, Frédéric Huet, , Alexandre Fabre

The paper identifies biallelic UNC45A mutations as the cause of O2HE syndrome, characterized by cholestasis, congenital diarrhea, hearing loss, and bone fragility.

bioRxiv · Oct 26, 2017 · PreprintGenetics