Andrew James Macpherson

Microbiota during early life windows orchestrates intestinal maturation and barrier formation in the offspring

This study shows that maternal and postnatal microbiota influence intestinal epithelial maturation and barrier formation through epigenetic and transcriptional mechanisms in offspring.

Low abundant intestinal commensals modulate immune control of chronic myeloid leukemia stem cells

This study identifies Sutterella wadsworthensis as a low-abundant intestinal commensal that suppresses anti-leukemia immune responses in chronic myeloid leukemia.

Colitis-primed circulating T cells drive small intestinal barrier function through Nod2, microbiota and myosin light chain kinase-dependent mechanisms

This study shows that colitis-primed T cells affect small intestinal barrier function via Nod2, microbiota, and MLCK mechanisms, with distinct roles for hematopoietic and non-hematopoietic Nod2.

Component specific responses of the microbiomes to common chemical stressors in the human food chain

This study examines how chemical stressors affect microbiomes across different food chain components, finding component-specific responses and shifts in microbial composition and stability.

Innate immune system signaling and CD11b+CD11c+CD103+ cell migration to the brain underlie changes in mouse behavior after microbial colonization.

This study identifies innate immune signaling and CD11b+CD11c+CD103+ cell migration to the brain as mechanisms linking microbial colonization to behavioral changes in mice.

Microbiota-derived short chain fatty acids promote Aβ plaque deposition

This study shows that microbiota-derived short chain fatty acids (SCFA) increase Aβ plaque deposition in Alzheimer's disease by promoting microglial activation and ApoE upregulation.

Accurate identification and quantification of commensal microbiota bound by host immunoglobulins

This paper introduces an optimized IgA-Seq protocol and a novel probability-based scoring method to accurately identify and quantify commensal gut microbiota bound by host immunoglobulins.

Neuronal programming by microbiota enables environmental regulation of intestinal motility

The paper shows microbiota induce AhR in enteric neurons, enabling them to respond to environmental signals.