Evolution of affinity between p53 and MDM2 across the animal kingdom demonstrates high plasticity of motif-mediated interactions
Filip Mihalič, Emma Åberg, Pouria Farkhondehkish, Niels Theys, Eva Andersson, Per Jemth
The paper examines the evolution of p53/MDM2 interaction affinity across species, finding significant variation in binding strength and suggesting plasticity in motif-mediated interactions.
Protein Science · May 22, 2023Peer-reviewedMolecular Biology