Conservation of affinity rather than sequence underlies a dynamic evolution of the motif-mediated p53/MDM2 interaction in teleosts
Filip Mihalič, Dahiana Arcila, Mats E. Pettersson…·Per Jemth
The paper investigates the evolution of p53/MDM2 interaction in teleosts, finding that affinity is conserved through compensatory changes in both conserved and non-conserved regions.