Author
Uppsala UniversityORCID 0000-0003-1516-7228Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Caroline Benz, Lars Maassen, Leandro Simonetti…·Ylva Ivarsson
This study uses phage-based deep mutational scanning to identify binding determinants of short linear motifs between human and SARS-CoV-2 proteins, refining motifs and identifying affinity-enhancing mutations.
Filip Mihalič, Dahiana Arcila, Mats E. Pettersson…·Per Jemth
The paper investigates the evolution of p53/MDM2 interaction in teleosts, finding that affinity is conserved through compensatory changes in both conserved and non-conserved regions.
Filip Mihalič, Caroline Benz, Eszter Kassa…·Ylva Ivarsson
The paper identifies SARS-CoV-2 protein domains that interact with human peptides and discovers antiviral peptides targeting Nsp9 and Nsp16.
Weihua Ye, Phani Rama Krishna Behra, Karl Dyrhage…·Per Jemth
The paper identifies new proteins in Apilactobacillus kunkeei that adopt alpha-helical folded states, suggesting de novo protein emergence is common in evolution.
Filip Mihalič, Emma Åberg, Pouria Farkhondehkish…·Per Jemth
The paper examines the evolution of p53/MDM2 interaction affinity across species, finding significant variation in binding strength and suggesting plasticity in motif-mediated interactions.
Louise Vagner Laursen, Jelena Čalyševa, Toby J. Gibson, Per Jemth
The paper reconstructs and resurrects ancestral sequences of PDZ3 and CRIPT to study the evolutionary dynamics of their interaction, finding it ancient but with reduced affinity in nematodes and insects.