Ectopic expression of two cone opsins in mouse RGCs results in opposite responses to light stimulation, likely due to differential G protein activation
Marco Rucli, Nika Vrabic, Corentin Joffrois, Antoine Chaffiol, Mélissa Desrosiers, Serge A. Picaud, Olivier Marre, Stefan Herlitze, Deniz Dalkara
This study shows that expressing short-wavelength cone opsin in RGCs causes hyperpolarization, opposite to mid-wavelength opsin's depolarization, due to different G-protein activation.
bioRxiv · Sep 10, 2025 · PreprintNeuroscience