Author

Qin Huang

Broad InstituteORCID 0000-0002-7170-7455Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Qin Huang2 papers · University of Pennsylvania

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

Alexander SvanbergssoniD· 2 shared Benjamin E. DevermaniD· 2 shared Jencilin Johnston· 2 shared John W. HarveyiD· 2 shared Ken Y. ChaniD· 2 shared Pamela P. Brauer· 2 shared Qingxia ZhengiD· 2 shared Simon Pacouret· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Alexander SvanbergssonORCID

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2 papers

Recent·Most cited

BI-TfR1 CapX rapidly transits the blood-brain barrier for efficient, low-dose gene delivery throughout the CNS

Ken Y. Chan, Chin-Yen Lin, Qin Huang, Simon Pacouret, Qingxia Zheng, John W. Harvey, Pamela P. Brauer, Jencilin Johnston, Fiona E. Serack, Jessie R. Davis, Nikita G Kamath, Saša Jereb, Daniel A. Sprague, Alexander Svanbergsson, Magalie Boucher, , Benjamin E. Deverman

The paper describes BI-TfR1 CapX, a gene delivery vector that efficiently crosses the blood-brain barrier, transduces CNS neurons and astrocytes, and reduces Prnp mRNA with low doses.

bioRxiv · Sep 29, 2026 · PreprintNeuroscience

An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery

Qin Huang, Ken Y. Chan, Jason Hongliu Wu, Nuria Roxana Botticello-Romero, Qingxia Zheng, Shan Lou, Casey Keyes, Alexander Svanbergsson, Jencilin Johnston, Allan Mills, C.-L. Lin, Pamela P. Brauer, Gabrielle Clouse, Simon Pacouret, John W. Harvey, , Benjamin E. Deverman

The paper develops a modified AAV capsid that targets the human Transferrin Receptor to enhance gene delivery to the CNS, showing improved reporter expression and therapeutic potential for Gaucher disease.

Science · May 16, 2024Peer-reviewedNeuroscience