Polycystin-1 acts as an atypical adhesion GPCR that responds to novel Wnt signaling and mechanical stimuli
Nikolay Gresko, Valeria Padovano, Peder Berg, Albert C.M. Ong, Stefan Somlo, Nicole Scholz, Tobias Langenhan, Michael J. Caplan
This paper identifies Polycystin-1 as an atypical adhesion GPCR that activates a signaling pathway through Wnt ligands and mechanical stimuli, leading to GSK3 inhibition and ciliary removal.
bioRxiv · May 21, 2025 · PreprintCell Biology