Hexokinase-I directly binds to a charged membrane-buried glutamate of mitochondrial VDAC1 and VDAC2
Sebastian Bieker, Michael Timme, Nils Woge, D. G. Hassan, Chelsea M. Brown, Siewert J. Marrink, Manuel N. Melo, Joost C. M. Holthuis
This study identifies a charged glutamate on VDAC1 and VDAC2 that interacts with HKI's N-terminal helix, revealing structural and mechanistic insights into their complex formation.
Communications Biology · Feb 10, 2025Peer-reviewedBiochemistry