Manuel N. Melo

This study shows ceramides disrupt VDAC-HKI complex assembly by modulating VDAC tilt and membrane thinning, revealing a mechanism for ceramide-induced apoptosis.

The paper develops an in vitro assay to study HKI-VDAC1 complex assembly and shows the critical role of a bilayer-facing glutamate in pH-sensitive binding.

This paper introduces an enhanced G[o]Martini model that improves protein dynamics simulation and addresses inaccuracies in the Martini protein model through diverse case studies.

This study identifies a charged glutamate on VDAC1 and VDAC2 that interacts with HKI's N-terminal helix, revealing structural and mechanistic insights into their complex formation.