Canagliflozin reprograms the aging hippocampus in genetically diverse UM-HET3 mice and attenuates Alzheimer's-like pathology
Hashan S. M. Jayarathne, Dulmalika Herath Manchanayake, Ryan P. Sullivan, Nina Chimienti, Omar Kadri, Katherine Gurdziel, Seongho Kim, Hyejeong Jang, Brett C. Ginsburg, Richard A. Miller, Shoshana Yakar, Marianna Sadagurski
This study investigates how canagliflozin affects brain aging and Alzheimer's-like pathology in mice, finding sex-specific effects on hippocampal function and disease markers.
Aging Cell · Oct 5, 2025Peer-reviewedNeuroscience