Hydrogen peroxide formation by Nox4 limits malignant transformation
Valeska Helfinger, Florian Freiherr von Gall, Nina Henke, Michael M. Kunze, Tobias Schmid, Juliana Heidler, Ilka Wittig, Heinfried H. Radeke, Viola Marschall, Karen Anderson, Ajay M. Shah, Simone Fulda, Bernhard Brüne, Ralf P. Brandes, Katrin Schröder
The paper shows that Nox4 produces hydrogen peroxide, which prevents malignant transformation by regulating DNA repair and AKT activity.
bioRxiv · Aug 16, 2017 · PreprintCancer Biology