Karen Anderson

A Translational Reference for Green Autofluorescence Imaging in the Rhesus Macaque Eye using the OcuMet Beacon

This study establishes normative green autofluorescence (GAF) values in rhesus macaques across different retinal regions and links GAF to age, intraocular pressure, and retinal structure.

Exogenous Nav1.1 activity in excitatory and inhibitory neurons reverts Dravet syndrome comorbidities when delivered post-symptom onset in mice with Dravet

This study shows that delivering a modified SCN1A gene via viral vectors to DS mice improves survival, reduces seizures, and corrects brain activity after symptom onset.

Early hippocampal hyperexcitability followed by disinhibition in a mouse model of Dravet syndrome

The paper analyzes the activity of hippocampal neurons in a mouse model of Dravet syndrome across different disease stages, finding temporary excitability increases in pyramidal neurons and persistent inhibition deficits in interneurons.

Hydrogen peroxide formation by Nox4 limits malignant transformation

The paper shows that Nox4 produces hydrogen peroxide, which prevents malignant transformation by regulating DNA repair and AKT activity.